15 research outputs found
Recruitment, Preparation, Retention: A case study of computing culture at the University of Illinois at Urbana-Champaign
Computer science is seeing a decline in enrollment at all levels of
education, including undergraduate and graduate study. This paper reports on
the results of a study conducted at the University of Illinois at
Urbana-Champaign which evaluated students attitudes regarding three areas which
can contribute to improved enrollment in the Department of Computer Science:
Recruitment, preparation and retention. The results of our study saw two
themes. First, the department's tight research focus appears to draw
significant attention from other activities -- such as teaching, service, and
other community-building activities -- that are necessary for a department's
excellence. Yet, as demonstrated by our second theme, one partial solution is
to better promote such activities already employed by the department to its
students and faculty. Based on our results, we make recommendations for
improvements and enhancements based on the current state of practice at peer
institutions.Comment: 37 pages, 13 figures. For better quality figures, please download the
.pdf from
http://www.cs.uiuc.edu/research/techreports.php?report=UIUCDCS-R-2007-281
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated through gene regulation. Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association. We confirmed that the T2D risk allele for this SNP increases FOXA2-bound enhancer activity in islet- and liver-derived cells. We observed allele-specific differences in NEUROD1 binding in islet-derived cells, consistent with evidence that the T2D risk allele increases islet MTNR1B expression. Our study demonstrates how integration of genetic and genomic information can define molecular mechanisms through which variants underlying association signals exert their effects on disease
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip involving 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two demonstrating sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of further common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signalling and cell cycle regulation, in diabetes pathogenesis
Architectural Reference Models For Safety-Critical Systems
In 2001, Lui Sha published a paper entitled "Using Simplicity to Control Complexity." It describes an architecture that switches between a high-assurance control subsystem and a high-performance-control subsystem. But his solution is much bigger and can be more widely applied; the Simplex architecture is a solution-creating technique for combining two algorithms such that a system retains the safety of the first while gaining the features of the second.
Using this architecture has been difficult because it has not been clear what kinds of problems the Simplex architecture solves; neither has it been clear in what ways developers can describe Simplex to conduct an early analysis of their own Simplex-based designs.
Simply put, my work is as much about Simplex as it is about describing Simplex architectures. This dissertation provides a collection of precise, logical descriptions of the Simplex architecture in four different modeling paradigms. I also describe my implementation of a Simplex architecture in a distributed control environment
Ten Years toward Equity: Preliminary Results from a Follow-Up Case Study of Academic Computing Culture
Just over 10 years ago, we conducted a culture study of the Computer Science Department at the flagship University of Illinois at Urbana-Champaign, one of the top five computing departments in the country. The study found that while the department placed an emphasis on research, it did so in a way that, in conjunction with a lack of communication and transparency, devalued teaching and mentoring, and negatively impacted the professional development, education, and sense of belonging of the students. As one part of a multi-phase case study spanning over a decade, this manuscript presents preliminary findings from our latest work at the university. We detail early comparisons between data gathered at the Department of Computer Science at the University of Illinois at Urbana-Champaign in 2005 and our most recent pilot case study, a follow-up research project completed in 2016. Though we have not yet completed the full data collection, we find it worthwhile to reflect on the pilot case study data we have collected thus far. Our data reveals improvements in the perceptions of undergraduate teaching quality and undergraduate peer mentoring networks. However, we also found evidence of continuing feelings of isolation, incidents of bias, policy opacity, and uneven policy implementation that are areas of concern, particularly with respect to historically underrepresented groups. We discuss these preliminary follow-up findings, offer research and methodological reflections, and share next steps for applied research that aims to create positive cultural change in computing
A Pattern for Adaptive Behavior in Safety-Critical, Real-Time Middleware
Abstract — Patterns are a valuable method for communicating software engineering expertise about proven solutions for common problems. This paper evaluates the use of domainindependent patterns in a case study of Etherware, a middleware for networked control with a real-time, safety-critical applications model. The case study illustrates the positive and negative impact that four existing patterns have on availability, reliability, and robustness for real-time, safety-critical systems. From the results of the case study, we present the Adaptive Control Filter, a design pattern for real-time, safety-critical middleware which can mitigate timing dependencies in networked control. I